Wednesday, March 20, 2019

Quote of the Day

Have no mean hours, but be grateful for every hour, and accept what it brings. The reality will make any sincere record respectable. No day will have been wholly misspent, if one sincere, thoughtful page has been written. Let the daily tide leave some deposit on these pages, as it leaves sand and shells on the shore. So much increase of terra firma. this may be a calendar of the ebbs and flows of the soul; and on these sheets as a beach, the waves may cast up pearls and seaweed.

- Henry David Thoreau

Tuesday, March 19, 2019

Quote of the Day

As a single footstep will not make a path on the earth, so a single thought will not make a pathway in the mind. To make a deep physical path, we walk again and again. To make a deep mental path, we must think over and over the kind of thoughts we wish to dominate our lives.

- Henry David Thoreau

Sunday, March 17, 2019

Quote of the Day

Accustom yourself to the belief that death is of no concern to us, since all good and evil lie in sensation and sensation ends with death. Therefore the true belief that death is nothing to us makes a mortal life happy, not by adding to it an infinite time, but by taking away the desire for immortality. For there is no reason why the man who is thoroughly assured that there is nothing to fear in death should find anything to fear in life. So, too, he is foolish who says that he fears death, not because it will be painful when it comes, but because the anticipation of it is painful; for that which is no burden when it is present gives pain to no purpose when it is anticipated. Death, the most dreaded of evils, is therefore of no concern to us; for while we exist death is not present, and when death is present we no longer exist. It is therefore nothing either to the living or to the dead since it is not present to the living, and the dead no longer are.

- Epicurus, Letter to Menoeceus

Saturday, March 16, 2019

Wisdom Of The Week

In 1992, the AIDS/HIV “parallel track” was approved as a regulatory change for FDA to allow patients exclusive access to AIDS/HIV drugs that had passed safety tests but had not yet passed all efficacy tests. Other drugs did not have access to this approval option. As a result of parallel track, the highly effective anti-viral drug stavudine was approved, saving thousands of lives.

…In the years that followed, FDA and Congress created several paths to speed approval and open access to promising medications, including accelerated approval, priority review, fast track, breakthrough therapy, right to try, and expanded access, or “compassionate use.” Unfortunately, these approaches are often confusing, and it is difficult for drug developers to determine which approach to pursue. None of these reforms have matched the openness and simplicity of the parallel track…


- Alex Tabarrok

Quote of the Day

What we desire makes us vulnerable.

- Ryan Holiday, The Daily Stoic

Friday, March 15, 2019

Quote of the Day

Reading Plutarch, he lost awareness of the gap in time that divided them—much bigger than the gap between Montaigne and us. It does not matter, he wrote, whether a person one loves has been dead for fifteen hundred years or, like his own father at the time, eighteen years. Both are equally remote; both are equally close. Montaigne’s merging of favorite authors with his own father says a lot about how he read: he took up books as if they were people, and welcomed them into his family.

- Sarah Bakewell, How to Live: A Life of Montaigne in One Question and Twenty Attempts at an Answer

Thursday, March 14, 2019

Quote of the Day

We forget: In life, it doesn’t matter what happens to you or where you came from. It matters what you do with what happens and what you’ve been given.

- Ryan Holiday, The Obstacle is the Way

Wednesday, March 13, 2019

Quote of the Day

We are attracted by wealth, pleasures, good looks, political advancement and various other welcoming and enticing prospects: we are repelled by exertion, death, pain, disgrace and limited means. It follows that we need to train ourselves not to crave the former and not to be afraid of the latter. Let us fight the battle the other way round - retreat from the things that attract us and rouse ourselves to meet the things that actually attack us.

- Seneca, Letters to a Stoic

Tuesday, March 12, 2019

Quote of the Day

We are independent of the change we detect. The longer the lever, the less perceptible its motion. It is the slowest pulsation which is the most vital. The hero then will know how to wait, as well as to make haste. All good abides with him who waiteth wisely; we shall sooner overtake the dawn by remaining here than by hurrying over the hills of the west.

- Henry David Thoreau