Saturday, October 13, 2012

Combating "Social Intelligence" of Cancer Cells

One of the authors, physicist Eshel Ben-Jacob of Tel Aviv University in Israel, has argued for some time that many single-celled organisms, whether they are tumour cells or gut bacteria, show a rudimentary form of social intelligence – an ability to act collectively in ways that adapt to the prevailing conditions, learn from experience and solve problems, all with the “aim” of improving their chances of survival. He even believes there is evidence that they can modify their own genomes in beneficial ways.

Many bacteria can engage in similar feats of communication and coordination, which can produce complex colony shapes such as vortex-like circulating blobs or exotic branching patterns. These displays of “social intelligence” help the colonies survive adversity, sometimes to our cost. Biofilms, for example – robust, slimy surface coatings that harbour bacteria and can spread infection in hospitals – are manufactured through the co-operation of several different species.

But as cyberwarfare experts know, disrupting communications can be deadly, and the same social intelligence that helps bacteria thrive can be manipulated to attack pathogenic varieties. Some strategies for tackling dangerous bacteria now target their cell-to-cell communications, for example by introducing false signals that might induce cells to eat one another or to dissolve biofilms. So it pays to know what they’re saying to one another.

Ben-Jacob, along with Donald Coffey of the Johns Hopkins University School of Medicine in Baltimore and “biological physicist” Herbert Levine of Rice University in Houston, Texas, think that we should be approaching cancer therapy this way too: not by aiming to kill off tumour cells with lethal doses of poisons or radiation, but by interrupting their conversations.


- More Here

No comments: