Friday, February 27, 2015

Microbes R Us !!

This week has been full of Microbes news!!

My No-Soap, No-Shampoo, Bacteria-Rich Hygiene Experiment:

My skin began to change for the better. It actually became softer and smoother, rather than dry and flaky, as though a sauna’s worth of humidity had penetrated my winter-hardened shell. And my complexion, prone to hormone-related breakouts, was clear. For the first time ever, my pores seemed to shrink. As I took my morning “shower” — a three-minute rinse in a bathroom devoid of hygiene products — I remembered all the antibiotics I took as a teenager to quell my acne. How funny it would be if adding bacteria were the answer all along.

Allergy Risk May Be Tied to How You Wash Your Dishes:

The findings demonstrated only an association, not cause and effect, so it was not clear whether these behaviors directly led to fewer allergies. But it may be the case that these behaviors expose children to innocuous bacteria, which can help strengthen their immune systems, said Bill Hesselmar, an assistant professor at the University of Gothenburg and lead author of the study.

Finally, Rob Knight brilliant TED talk:

And we've just over the last few years found out that the microbes in different parts of the body are amazingly different from one another. So if I look at just one person's microbes in the mouth and in the gut, it turns out that the difference between those two microbial communities is enormous. It's bigger than the difference between the microbes in this reef and the microbes in this prairie. So this is incredible when you think about it. What it means is that a few feet of difference in the human body makes more of a difference to your microbial ecology than hundreds of miles on Earth.

And this is not to say that two people look basically the same in the same body habitat, either. So you probably heard that we're pretty much all the same in terms of our human DNA. You're 99.99 percent identical in terms of your human DNA to the person sitting next to you. But that's not true of your gut microbes: you might only share 10 percent similarity with the person sitting next to you in terms of your gut microbes. So that's as different as the bacteria on this prairie and the bacteria in this forest.

So these different microbes have all these different kinds of functions that I told you about, everything from digesting food to involvement in different kinds of diseases, metabolizing drugs, and so forth. So how do they do all this stuff? Well, in part it's because although there's just three pounds of those microbes in our gut, they really outnumber us. And so how much do they outnumber us? Well, it depends on what you think of as our bodies. Is it our cells? Well, each of us consists of about 10 trillion human cells, but we harbor as many as 100 trillion microbial cells. So they outnumber us 10 to one. Now, you might think, well, we're human because of our DNA, but it turns out that each of us has about 20,000 human genes, depending on what you count exactly, but as many as two million to 20 million microbial genes. So whichever way we look at it, we're vastly outnumbered by our microbial symbionts. And it turns out that in addition to traces of our human DNA, we also leave traces of our microbial DNA on everything we touch. We showed in a study a few years ago that you can actually match the palm of someone's hand up to the computer mouse that they use routinely with up to 95 percent accuracy.






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