Friday, August 1, 2014

Using Mummy's to Decipher Heart Disease

We think of heart disease as a modern scourge, brought on by our sedentary lifestyles and our affinity for fast food. But a few years ago, a team of researchers discovered something puzzling — CT scans of Egyptian mummies showed signs of hardened, narrow arteries. Further scans of mummies from other ancient civilizations turned up the same thing.

How could it be that these preindustrial people without donuts or desk jobs suffered from atherosclerosis, a condition we know to be associated with smoking, unhealthy diet and lack of exercise? And what does that tell us about heart disease today?

We may be getting closer to understanding. In a study published this week in Global Heart, researchers conclude that factors like inhaling smoke from open fire pits, and inflammation triggered by dirty living conditions may be to blame.

While inflammation isn't considered one of the main risk factors for heart disease today, studies have found that it's associated with atherosclerosis. And ongoing clinical trials are testing whether reducing inflammation might help reduce risk of heart disease.

Since female mummies showed more evidence of atherosclerosis than male mummies, the scientists also theorize that exposure to smoke from fire pits played a role. "In each of the cultures we studied, the women were cooking," says Dr. Greg Thomas, a cardiologist who led the study. These ancient peoples also used fires to keep warm and ward off insects, he says, "So they were exposed to a lot of smoke." In many ways, inhaling billowing smoke from a fire pit can be as harmful to the heart as smoking cigarettes or breathing highly polluted air, Thomas notes.


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