Obesity and Brain Damage

Here - Other than the obvious reasons, more:

"Why fatness should affect the brain in this way is not clear, although a host of culprits have been suggested. A paper published this week in the early edition of Proceedings of the National Academy of Sciences has identified a gene that seems to be involved. FTO, as the gene is known, appears to play a role in both body weight and brain function. This gene comes in different versions; one version — let’s call it “troublesome”— appears to predispose people to obesity. Individuals with two copies of the troublesome version tend to be fatter than those with only one copy of it, who in turn tend to be fatter than those with two copies of the “regular” version. Now, the troublesome form has been linked to atrophy in several regions of the brain, including the frontal lobes, though how and why it has this effect remains unknown.

Diet may play a role, too. Studies in mice have shown that eating a very-high-fat diet increases brain inflammation and disrupts brain function. And the onset of brain decay may itself play a part. Since the regions of the brain most affected by obesity appear to be those involved in self-control and the regulation of appetite, erosion of these abilities may lead to greater obesity, which may lead to more rapid brain erosion, in a downward spiral."

On a positive note - 10 great ideas to beat obesity here.