Thursday, April 18, 2019

Brain-Derived Neurotrophic Factor & Exercise

Every time you work out, your muscles, fat cells, and liver release a variety of molecules into the bloodstream. Some of these molecules circulate through the body and travel up to the brain, where they cross the blood-brain barrier. Once inside, they trigger a cascade of beneficial changes that can make you feel sharper and happier.

One of the most crucial changes is the release of a growth hormone called brain-derived neurotrophic factor, or BDNF. When it comes to exercise’s positive effects on the brain, BDNF is the star.

“This is one of the most important molecules for brain function in connection to the effects of exercise,” says Gomez-Pinilla. “BDNF is very important for all of the basic processes related to learning and memory in the brain.”

BDNF helps the brain build new connections, or synapses, between neurons — a process called synaptic plasticity that is thought to be the foundation for learning. Cells communicate through these connections both within and across areas of the brain. For example, neurons in the hippocampus create synapses with cells in the prefrontal cortex, another region that significantly benefits from exercise. The prefrontal cortex is where a lot of our higher-level executive functions originate, like decision-making and attention, processes that are also improved with exercise.


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