Like proteins, messenger RNAs are long chainlike molecules composed of building blocks. The four building blocks that make up messenger RNAs form what is known as the genetic code. As their name implies, messenger RNAs carry messages: messages that are translated by your body in order to create proteins. Thus messenger RNAs are the language of life. And the human body has a lot to say.
[---]
mRNA's are transient. The amount of protein produced is dependent on how much of that mRNA is present. And they can be induced over and over again to produce the same effect. So wow, it seems so simple. If we could treat a disease, if there's a protein that's missing to treat a disease, then we could simply give a few copies of an mRNA to the body for it to produce that protein. If that protein's only needed once, then maybe a single dose would suffice. If a protein is needed multiple times, then we can dose mRNA over and over again. And that's exactly what's happening. So when I went on clinicaltrials.gov this morning, it turns out that there are over 175 clinical trials now open using mRNA-based medicines that are recruiting patients. Another 54 clinical trials are waiting in the [wings], ready to be opened. So there is a coming tsunami of mRNA medicines.
[---]
And for cancer patients, we're creating personalized cancer vaccines. These vaccines are meant to train their bodies, their immune systems, to attack their cancers. These are truly personalized medicines, one vaccine for one person.
[---]
Now for personalized cancer vaccines to be the most effective, we need to get them made and back to the patient as quickly as possible. We aim for a turnaround time of 45 days. By January of 2020, we had already manufactured, quality-controlled and delivered to several dozen patients personalized cancer vaccines. So we had the know-how and the capacity to manufacture vaccines quickly. Thus, when the sequence of the SARS-CoV-2 virus was posted to a public web server on January 10, 2020, we got immediately to work. Within two days, we had agreed with our collaborators at NIH on exactly which form of the spike protein to put in our vaccine. Because we had done so so many times before, it then took our mRNA design team just one hour to design the mRNA that we immediately put on to our manufacturing equipment. We were then able to make that RNA, get it quality-controlled, fill-finished and shipped off to NIH for the clinical trial in 45 days.
What I find truly remarkable is that that mRNA sequence that took us one hour to design is the same mRNA sequence that went into your arms, that ended up in Spikevax, our now fully approved vaccine. One hour to design a medicine that has saved countless lives.
[---]
Having learned to speak the language of mRNA, the language of life, we can now use it to create medicines that are just for one person, like a personalized cancer vaccine, or can be rapidly produced and distributed to entire populations, like the COVID-19 vaccines. And the best part? The best part is we're simply tapping into your body's own ability to make its own medicines.
- Melissa J. Moore, RNA researcher
I was upset about the insanity of anti-vaccination but yet I prefer to live in a world where diversity of compliance (amongst other things as long as it doesn't cause pain and suffering) thrives. Otherwise, this blue planet will be one big North Korea. People should not follow trends blindly and learn to pause and question everything to distill the truth.
Diversity instigates randomness which feeds the complex systems and in turn helps with evolution albeit we don't know if that evolution would be good for humans or not.
The main issue is here is not polarization of vaccination compliance but its the skin in the game.
- If you don't "believe" (whatever crap that means) in vaccine because you don't like to follow orders other than self or for the love of your tribe then you should write it in your will and promise yourself that you will never take mRNA vaccine for cancer or any other disease you would (not might) encounter as you grown old.
- If you "believe" (whatever crap that means) in vaccine because of your love for your tribe and with no understanding nor appreciation of science and dedicated humans behind it and you do so to prove that other side is wrong and in the end you do it for virtue signaling then you should start donating your medical data to help with cancer and other research since "other" side doesn't do that.
- If you have gratitude that we live in a place and time where innovation in medicine thrives and helps to reduce pain and suffering then I salute you. Understand, these innovations means that we don't have to test on animals for medicine. Please, speak up against animal testing (FDA, your senator etc.) because it not only causes immense sufferings on animals but it is a barricade for future innovation in medicine. You or your loved will be a victim of it sooner or later.
It is extremely sad that a virus and a break through in medicine has also become a victim of political polarization. As much as it makes me sad, I understand this is part of evolution unfolding in front of our eyes and I am grateful we haven't become North Korea.
I will try to explain in simplistic terms for people not driven by ideology nevertheless got caught in the fear mongering:
- With vaccination, you are training your immunity (by inducing the corresponding protein if you have it or propagating the protein if you don't have it) to prepare for the defense when covid comes home.
- If you don't take the vaccine and prefer the natural immunity to open up the defense when covid comes home then you are skipping the training the immunity and going into war with no training. It might work. "Might" is the word. But it will not work if you don't have the protein. This is the key difference.And also understand the difference between sterilizing immunity and non-sterilizing immunity of vaccines based on different virus (think small pox and covid, former is sterilizing while the later is not).
There is slight probability that you will die of choking every time you eat but yet you eat everyday. Most food made by corporations fucks with your immunity and factory farm dead bodies of animals who went through hell on earth will certainly fuck with your immunity.
Like everything else in life there is a probability that mRNA vaccine might kill you or fuck with your immunity but its much lesser than the probability of covid fucking with your immunity or killing you.
This is one of my favorite scenes from the movie Zero Dark Thirty and how Maya's character struggles to explain the difference between certainty and probability.
[In a CIA Conference room with CIA Director, his deputies and Maya]
CIA Director: I'm about to go look the President in the eye, and what I'd like to know, no fucking bullshit, is where everyone stands on this thing. Now, very simply, is he there, or is he not fucking there?
Deputy Director: We all come at this through the filter of our own past experiences. I remember "Iraq WMD" very clearly, I fronted that, and I can tell you the case for that was much stronger than this case.
CIA Director: A fuckin' yes or a no.
Deputy Director: We don't deal in certainty, we deal in probability. I'd say there's a sixty percent probability he's there.
The Wolf: I concur. Sixty percent.
George: I'm at eighty percent. Their OPSEC is what convinces me.
CIA Director: You guys ever agree on anything?
Dan: Well, I agree with sixty, we're basing this mostly on detainee reporting and I spent a bunch of time in those rooms. Who knows? I'd say it's a soft sixty, sir. I'm virtually certain there's some high value target there, I'm just not sure it's bin Laden.
CIA Director: This is a cluster-fuck, isn't it?
Jeremy: I'd like to know what Maya thinks...
Deputy Director: We're all incorporating her assessment into ours...
Maya: A hundred percent he's (Osama bi Laden) there. Okay, fine, ninety-five percent because I know how certainty freaks you guys out, but it's a hundred.
No comments:
Post a Comment