Thursday, February 9, 2012

I, Robopsychologist

In I, Robot, the blockbuster movie adapted from Asimov’s robot stories, Calvin sums up her job description by saying, “I make robots seem more human.” If I had to sum up my main goal as a robopsychologist, it would be “to make machines think and learn like humans,” and ultimately, replicate creative cognition in AI. Lofty goal? Perhaps. Possible? I believe it is. I’ll be honest, though—I haven’t always thought this way.

The main reason for my past disbelief is because most of the people working on AI discounted the input of psychology. They erroneously thought they could replicate humanity in a machine without actually understanding human psychology. Seems like a no-brainer to me: If you want to replicate human-like thinking, collaborate with someone who understands human thinking on a fundamental and psychological level, and knows how to create a lesson plan to teach it. But things are changing. The field of AI is finally, slowly starting to appreciate the important role psychology needs to play in their research


- More Here


Quote of the Day

"The ultimate aim of government is not to rule, or restrain, by fear, nor to exact obedience, but contrariwise, to free every man from fear, that he may live in all possible security; in other words, to strengthen his natural right to exist and work without injury to himself or others. No, the object of government is not to change men from rational beings into beasts or puppets, but to enable them to develope their minds and bodies in security, and to employ their reason unshackled; neither showing hatred, anger, or deceit, nor watched with the eyes of jealousy and injustice. In fact, the true aim of government is liberty."

- Spinoza

Wednesday, February 8, 2012

The Creative Destruction of Medicine - Eric Topol

Review of Eric Topol's call for personalized medicine in his new book, The Creative Destruction of Medicine: How the digital revolution will create better health care.

"It's compelling stuff. Even if they don't cause harm, drugs often don't benefit most of the people who take them. Take Lipitor, a statin advertised as reducing the risk of heart attack by 36 per cent. Pfizer isn't lying with this claim, but closer reading reveals 2 per cent of patients taking Lipitor had heart attacks, compared with 3 per cent taking a placebo - or just 1 in 100 people will avoid a heart attack by taking the drug. Topol slaps you in the face with facts like these and shouts: "wake-up!"

The answer, he says, lies in technologies that tailor medicine to the individual - something that has long been talked about, but which is finally almost within reach. Almost, because although Topol tells some incredible tales of individuals with unexplained diseases having their genomes sequenced to find a cure, they remain in a minority. Individualised medicine for the masses is still a long way off, and although Topol provides a seductive vision of the future, he is vague on just how we get there.

That aside, the book provides an excellent summary of the current state of medical genetics and how fast it is progressing, with examples that may surprise even those working in medicine. As director of the Scripps Translational Science Institute in La Jolla, California, Topol is clearly abreast of the very latest developments, and the book feels extremely current."



What I've Been Reading

Quiet: The Power of Introverts in a World That Can't Stop Talking by Susan Cain (she is scheduled to give a TED talk this year). I wish this book come out when I was in my teens. I wish my old friends read this book. I wish my future friends read this book. I wish women in my life read this book. I wish... but thank you Susan for writing this book and "vindicating" us.
Technically, I am an introvert but far from being shy. I need alone time to "recharge", quite long walks with Max and all the hoopla of a quintessential introvert. Sadly that innateness comes with a social taboo. A decade ago, I decided to screw it and do what makes me happy; but with a catch that William James so eloquently put it a century ago.

A man has as many social selves as there are distinct groups of persons about whose opinion he cares. He generally shows a different side of himself to each of these different groups.
- William James



On Patience from Steve Wozniak's memoir, IWoz: Computer Geek to Cult Icon: How I Invented the Personal Computer, Co-Founded Apple, and Had Fun Doing It:
"I acquired a central ability that was to help me through my entire career: patience. I’m serious. Patience is usually so underrated. I mean, for all those projects, from third grade all the way to eighth grade, I just learned things gradually, figuring out how to put electronic devices together without so much as cracking a book.… I learned to not worry so much about the outcome, but to concentrate on the step I was on and to try to do it as perfectly as I could when I was doing it."


Group brainstorming doesn’t actually work:
Research by Marvin Dunnette.


E.O.Wilson's theory on public speaking anxiety:
"When our ancestors lived on the savannah, being watched intently meant only one thing: a wild animal was stalking us. And when we think we’re about to be eaten, do we stand tall and hold forth confidently? No. We run. In other words, hundreds of thousands of years of evolution urge us to get the hell off the stage, where we can mistake the gaze of the spectators for the glint in a predator’s eye. Yet the audience expects not only that we’ll stay put, but that we’ll act relaxed and assured. This conflict between biology and protocol is one reason that speechmaking can be so fraught. It’s also why exhortations to imagine the audience in the nude don’t help nervous speakers; naked lions are just as dangerous as elegantly dressed ones."


Introverts are sensitive (story of my life !!):
The highly sensitive tend to be philosophical or spiritual in their orientation, rather than materialistic or hedonistic. They dislike small talk. They often describe themselves as creative or intuitive. They dream vividly, and can often recall their dreams the next day. They love music, nature, art, physical beauty. They feel exceptionally strong emotions—sometimes acute bouts of joy, but also sorrow, melancholy, and fear. Highly sensitive people also process information about their environments—both physical and emotional—unusually deeply. They tend to notice subtleties that others miss—another person’s shift in mood, say, or a lightbulb burning a touch too brightly.
I
n most settings, people use small talk as a way of relaxing into a new relationship, and only once they’re comfortable do they connect more seriously. Sensitive people seem to do the reverse. They enjoy small talk only after they’ve gone deep. When sensitive people are in environments that nurture their authenticity, they laugh and chitchat just as much as anyone else.


Functional, moderate guilt:
This may promote future altruism, personal responsibility, adaptive behavior in school, and harmonious, competent, and prosocial relationships with parents, teachers, and friends. This is an especially important set of attributes at a time when a 2010 University of Michigan study shows that college students today are 40 percent less empathetic than they were thirty years ago, with much of the drop having occurred since 2000. (The study’s authors speculate that the decline in empathy is related to the prevalence of social media, reality TV, and “hyper-competitiveness.”)


From the book, Born to Be Good: The Science of a Meaningful Life by Dacher Keltner:
Keltner says that if he had to choose his mate by asking a single question at a speed-dating event, the question he would choose is: “What was your last embarrassing experience?” Then he would watch very carefully for lip-presses, blushing, and averted eyes. “The elements of the embarrassment are fleeting statements the individual makes about his or her respect for the judgment of others,” he writes. “Embarrassment reveals how much the individual cares about the rules that bind us to one another.”


Introverts are not smarter than extroverts (a.k.a stop stereotyping):
According to IQ scores, the two types are equally intelligent. Extroverts are better than introverts at handling information overload. Introverts’ reflectiveness uses up a lot of cognitive capacity, according to Joseph Newman. On any given task, he says, “if we have 100 percent cognitive capacity, an introvert may have only 75 percent on task and 25 percent off task, whereas an extrovert may have 90 percent on task.” This is because most tasks are goal-directed. Extroverts appear to allocate most of their cognitive capacity to the goal at hand, while introverts use up capacity by monitoring how the task is going.


When FLOW engulfs nothing else matters...
Important explanation for introverts who love their work may come from a very different line of research by the influential psychologist Mihaly Csikszentmihalyi on the state of being he calls “flow.” Flow is an optimal state in which you feel totally engaged in an activity—whether long-distance swimming or songwriting, sumo wrestling or sex. In a state of flow, you’re neither bored nor anxious, and you don’t question your own adequacy. Hours pass without your noticing. The key to flow is to pursue an activity for its own sake, not for the rewards it brings. Although flow does not depend on being an introvert or an extrovert, many of the flow experiences that Csikszentmihalyi writes about are solitary pursuits that have nothing to do with reward-seeking: reading, tending an orchard, solo ocean cruising. Flow often occurs, he writes, in conditions in which people “become independent of the social environment to the degree that they no longer respond exclusively in terms of its rewards and punishments. To achieve such autonomy, a person has to learn to provide rewards to herself.” In a sense, there are some activities that are not about approach or avoidance, but about something deeper: the fulfillment that comes from absorption in an activity outside yourself. Psychological theories usually assume that we are motivated either by the need to eliminate an unpleasant condition like hunger or fear or by the expectation of some future reward such as money, status, or prestige. But in flow, “a person could work around the clock for days on end, for no better reason than to keep on working.”


On Asian Culture:
Talk is for communicating need-to-know information; quiet and introspection are signs of deep thought and higher truth. Words are potentially dangerous weapons that reveal things better left unsaid. They hurt other people; they can get their speaker into trouble.
Has anyone read Amartya Sen's The Argumentative Indian? Between, I always wondered why Indians aren't usually considered typical "Asians" in US of A.


In Asian cultures, there’s often a subtle way to get what you want. It’s not always aggressive, but it can be very determined and very skillful. In the end, much is achieved because of it. Aggressive power beats you up; soft power wins you over.


On Free Trait Theory:
Introverts are capable of acting like extroverts for the sake of work they consider important, people they love, or anything they value highly. It explains how it’s possible for an extroverted scientist to behave with reserve in her laboratory, for an agreeable person to act hard-nosed during a business negotiation, and for a cantankerous uncle to treat his niece tenderly when he takes her out for ice cream. Free Trait Theory applies in many different contexts, but it’s especially relevant for introverts living under the Extrovert Ideal.


On Self-monitoring:
Self-monitors are highly skilled at modifying their behavior to the social demands of a situation. They look for cues to tell them how to act. When in Rome, they do as the Romans do, according to the psychologist Mark Snyder, author of Public Appearances, Private Realities, and creator of the Self-Monitoring Scale. To high self-monitors, low self-monitors can seem rigid and socially awkward. To low self-monitors, high self-monitors can come across as conformist and deceptive—“more pragmatic than principled.” But self-monitoring is an act of modesty. It’s about accommodating oneself to situational norms, rather than “grinding down everything to one’s own needs and concerns.” Not all self-monitoring is based on acting or on working the room. A more introverted version may be less concerned with spotlight-seeking and more with the avoidance of social faux pas.

On Restorative Niche:
“Restorative niche” is term for the place you go when you want to return to your true self. It can be a physical place, like the path beside the Richelieu River, or a temporal one, like the quiet breaks you plan between sales calls. It can mean canceling your social plans on the weekend before a big meeting at work, practicing yoga or meditation, or choosing e-mail over an in-person meeting. Acting out of character too long without restorative niches might lead to health and emotional issues. 


Introvert vs Extrovert couples:
The introverts desperately craving downtime and understanding from their partners, the extroverts longing for company, and resentful that others seemed to benefit from their partners’ “best” selves.

How to take care of an introverted child:
Remember that introverts react not only to new people, but also to new places and events. So don’t mistake your child’s caution in new situations for an inability to relate to others. He’s recoiling from novelty or overstimulation, not from human contact. As we saw in the last chapter, introversion-extroversion levels are not correlated with either agreeableness or the enjoyment of intimacy. Introverts are just as likely as the next kid to seek others’ company, though often in smaller doses.


Finally, remember to follow this simple rule in life:
Love is essential; gregariousness is optional.

Quote of the Day

“Never follow your dreams. Follow your effort.”

- Mark Cuban

Tuesday, February 7, 2012

Machine Ethics (Using Machine Learning)

Machine Ethics, a collection of essays edited by Michael Anderson and Susan Leigh Anderson (via here).

"The new field of machine ethics is concerned with giving machines ethical principles, or a procedure for discovering a way to resolve the ethical dilemmas they might encounter, enabling them to function in an ethically responsible manner through their own ethical decision making. Developing ethics for machines, in contrast to developing ethics for human beings who use machines, is by its nature an interdisciplinary endeavor. 
The essays in this volume represent the first steps by philosophers and artificial intelligence researchers toward explaining why it is necessary to add an ethical dimension to machines that function autonomously, what is required in order to add this dimension, philosophical and practical challenges to the machine ethics project, various approaches that could be considered in attempting to add an ethical dimension to machines, work that has been done to date in implementing these approaches, and visions of the future of machine ethics research."




The Iranian Genome Project

Yes, I was surprised too... more here from Razib and project home page here.

"The Iranian Genome Project aims to provide knowledge to both the scientific and Iranian community by studying and understanding the genetic background of Iranians.  Genomics is an emerging field whereby scientists map our genetic code — the language of life –  and study how differences in this language leads to differences in health and disease.  Knowledge of our genetic code will enable us, as Iranians, to gain a better understanding of how our genes affect our health.  Moreover, it will empower us as a community by giving us data that could one day be used to create tailored treatments and drugs.  As the age of personalized medicine begins, knowledge of genetic variation will be key in making sure that everyone’s unique needs are met."

Quote of the Day

"The greatest deception men suffer is from their own opinions."

- Leonardo da Vinci

Monday, February 6, 2012

Amazing Octopus - Mike deGruy




Review Of Lumigenix - New Personal Genome Service Company

We should be clear that there are many things that Lumigenix has done well, especially compared to companies occupying the lower end of the direct-to-consumer genetics market – this is absolutely not a cowboy operation. We particularly liked Lumigenix’s collaboration with the Mayo Clinic, which is a sensible way of obtaining reliable disease information without needing to invest heavily in in-house curation.

However, Lumigenix can’t help but suffer from comparisons to 23andMe, a company that beat it to market by over three years and now thoroughly dominates the direct-to-consumer genomics industry. The overall experience feels more-or-less likea less satisfying version of 23andMe: the common disease, trait and ancestry prediction systems are all broadly similar, but with a less sophisticated interface, and many of the more interesting components of the 23andMe service (such as carrier testing, pharmacogenomic markers, genome sharing, family inheritance patterns, Relative Finder) feel quite conspicuous in their absence. Then there’s the price: the Lumigenix test currently retails for USD$479 while 23andMe is USD$399 (without subscription).


- More Here